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General ADME filtering platform

2020-06-01 15:35:20
General ADME filtering platform
Detailed introduction:

◆ in vitro evaluation of drug absorption, distribution, metabolism and excretion (ADME)

▶  Study on drug permeability and transport in vitro

■ permeability of drugs studied by Caco-2 or mdckii-mdr1 monolayer cell model

■ Caco-2, mdckii-mdr1 cells and specific inhibitors for the study of transporter substrates and inhibitors

▶  Study on metabolic stability

■ study on the stability of drugs in liver microsomes (human, mouse, dog, monkey, etc.), S9, cytoplasm or hepatocytes

■ study on the stability of drugs in plasma, serum or whole blood

▶  Identification of metabolites and analysis of metabolic pathway in vitro

▶  Evaluation of drug solubility and chemical stability

▶  Study and evaluation of pre formulation

◆ pharmacokinetic evaluation of animals in vivo

▶  Bioavailability of various animal species (IV, PO)

■ rats, mice, dogs, monkeys, etc

▶  Kinetic evaluation of different routes of administration

■ intravenous, oral, intraperitoneal, subcutaneous and intramuscular injection, etc

▶  Tissue distribution and drug concentration measurement of various biological samples

■ plasma, whole blood, urine, feces, bile and tissues of the whole body, etc

▶  Analysis of drug excretion pathway and identification of metabolites in BDC rats


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