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Identification of CYP / UGT metabolizing enzymes

2020-06-01 15:35:42
Identification of CYP / UGT metabolizing enzymes
Detailed introduction:

◆ metabolic evaluation system of recombinase

▶  CYP1A2, CYP2B6, cyp2c8, CYP2C9, CYP2C19, CYP2D6, CYP2E1, CYP3A4, CYP3A5, etc

▶  UGT1A1, UGT1A3, UGT1A6, UGT1A9, ugt2b4, UGT2B7, UGT2B17, etc

▶  Others: FMOS, Maos, CES, etc

◆ liver microsomes + chemical inhibitors

◆ drug interaction evaluation based on CYP and UGT inhibition

▶  Reversible inhibition evaluation

▶  Evaluation of time-dependent (TDI) inhibition (or mechanism inhibition)

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