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Evaluation of efflux and uptake transporters

2020-06-01 15:36:08
Evaluation of efflux and uptake transporters
Detailed introduction:

◆ efflux transporter (efflux ratio, km, Vmax)

▶  Single expression system: MDCK / MDR1 (P-gp), MDCK / BCRP

▶  Double (CO) expression system: MDCK / mdr1-bcrp

◆ uptake of transporters (uptake%, km, Vmax)

▶  HEK293/OATPs:OATP1B1、1B3、2B1、1A2

▶  HEK293/OATs:OAT1、OAT3

▶  HEK293/OCTs:OCT2

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